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|Title: ||Femoral Neck Trabecular Microstructure in Ovariectomized Ewes Treated With Calcitonin: MRI Microscopic Evaluation|
|Authors: ||Jiang, Y.|
|Issue Date: ||2005|
|Publisher: ||New York : American Society for Bone and Mineral Research|
|Citation: ||JOURNAL OF BONE AND MINERAL RESEARCH, 20(1). p. 125-130|
|Abstract: ||Ovariectomy induces deterioration of the trabecular structure in the femoral neck of ewes, as
depicted by MR microscopic imaging. This structural deterioration is prevented by salmon calcitonin treatment.
Introduction: This study evaluated the trabecular (Tb) microarchitecture of an ovariectomy (OVX)-induced
osteoporotic model in ewes and determined the effects of salmon calcitonin (sCT), an osteoclast inhibitor, on
the Tb structure. This is the first report of OVX-induced changes in the Tb structure in the femoral neck in
the ewes and effect of sCT on the microarchitecture.
Materials and Methods: Ewes (5–8 years old, nr 28) were equally allocated into sham (Sham), OVX injected
with vehicle, or OVX injected with sCT at 50 or 100 IU, three injections per week. They were killed 6 months
after OVX. The femoral neck was examined with an MR imager at 9.4 T in axial, coronal, and sagittal planes.
An internal calibration procedure as a means of standardizing image analysis was used to adjust the segmentation
threshold. Data from all three planes were averaged.
Results and Conclusions: Compared with Sham, OVX induced significant changes (p < 0.0125) in the MRIderived
femoral neck Tb structure: Tb bone volume fraction (BV/TV), –18%; Tb number, –20%; Tb separation,
+23%; number of free ends, +28%; number of nodes, –39%; number of Tb branches, –23%; mean
length of Tb branches, –19%. Compared with OVX, treatment of sCT at 100 IU significantly improved all the
Tb structural parameters to the Sham level (p < 0.0001 p > 0.0281), whereas 50 IU significantly increased
the Tb number and the mean length of the Tb branches. BV/TV explained 74% of the variation of compressive
stress of the trabecular cylinder cores of the femoral neck. Combining all structural parameters in a multivariate
regression analysis significantly improved the explanation to 84%, and adding BMD further improved
the predictive ability of the model to 92%. We conclude that OVX induces deterioration of the MRI-derived
Tb microstructure in the femoral neck of ewes. sCT treatment prevents OVX-induced changes. The femoral
neck microarchitecture significantly correlates with its biomechanical properties. Combining microstructural
parameters with BMD further improves the prediction of bone biomechanical properties. The effects of
sCT on OVX ewes may help explain reduced fracture risk in postmenopausal osteoporotic women treated
|ISI #: ||000225986900019|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2006|
|Appears in Collections: ||Research publications|
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