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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/1004

Title: Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients
Authors: THEWISSEN, Marielle
LINSEN, Loes
SOMERS, Veerle
GEUSENS, Piet
RAUS, Jef
STINISSEN, Piet
Issue Date: 2005
Publisher: Oxford : Blackwell
Citation: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1051. p. 255-262
Abstract: Patients with T-cell-mediated autoimmune diseases show immune system abnormalities that resemble the typical characteristics of autoimmune dysfunction described in the elderly. In addition, the incidence of autoimmune disease increases with advancing age. To evaluate whether patients with rheumatoid arthritis (RA) and multiple sclerosis (MS) have premature immuno-senescence, we measured two indicators of aging: the number of T-cell-receptor excision circles (TRECs) and the percentage of CD4+CD28null T cells. We studied them in the peripheral blood mononuclear cells (PBMCs) of 60 RA patients, 32 MS patients, and 40 healthy controls (HCs). We found that TREC numbers were lower in RA and MS patients than in age-matched HCs, indicating premature thymic involution. Moreover, a subset of these patients contained age-inappropriate high frequencies of CD4+CD28null T cells. This study provides evidence of premature immune system senescence in both RA and MS patients. Premature aging could be a risk factor for developing autoimmune disorders in genetically predisposed individuals in a susceptible environment.
URI: http://hdl.handle.net/1942/1004
DOI: 10.1196/annals.1361.066
ISI #: 000233393100028
ISSN: 0077-8923
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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